SIRT2
神经退行性变
锡尔图因
组蛋白脱乙酰基酶
生物
帕金森病
毒性
多巴胺能
西妥因1
组蛋白脱乙酰酶抑制剂
组蛋白
疾病
神经科学
遗传学
基因
多巴胺
医学
下调和上调
内科学
乙酰化
作者
Tiago F. Outeiro,Eirene Kontopoulos,Stephen M. Altmann,Irina Kufareva,Katherine E. Strathearn,Allison Amore,Catherine B. Volk,Michele M. Maxwell,Jean‐Christophe Rochet,Pamela J. McLean,Anne B. Young,Ruben Abagyan,Mel B. Feany,Bradley T. Hyman,Aleksey Kazantsev
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2007-07-27
卷期号:317 (5837): 516-519
被引量:988
标识
DOI:10.1126/science.1143780
摘要
The sirtuins are members of the histone deacetylase family of proteins that participate in a variety of cellular functions and play a role in aging. We identified a potent inhibitor of sirtuin 2 (SIRT2) and found that inhibition of SIRT2 rescued α-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. Genetic inhibition of SIRT2 via small interfering RNA similarly rescued α-synuclein toxicity. Furthermore, the inhibitors protected against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease. The results suggest a link between neurodegeneration and aging.
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