血管生成
血管生成
转化生长因子β
背景(考古学)
内皮糖蛋白
转化生长因子β信号通路
内皮
BETA(编程语言)
细胞生物学
血管内皮生长因子B
转化生长因子
胚胎干细胞
内皮干细胞
生物
癌症研究
血管内皮生长因子
血管内皮生长因子A
遗传学
干细胞
基因
体外
血管内皮生长因子受体
古生物学
程序设计语言
计算机科学
川地34
标识
DOI:10.1016/s1359-6101(96)00048-2
摘要
Genetic studies have recently revealed a role for transforming growth factor-beta-1 (TGF-β1) and its receptors (TGF-βRs I and II as well as endoglin) in embryonic vascular assembly and in the establishment and maintenance of vessel wall integrity. The purpose of this review is threefold: first, to reassess previous studies on TGF-β and endothelium in the light of these recent findings; second, to describe some of the well-established as well as controversial issues concerning TGF-β and its regulatory role in angiogenesis; and third, to explore the notion of ‘context’ with respect to TGF-β and endothelial cell function. Although the focus of this review will be on the endothelium, other vascular wall cells are also likely to be important in the pathogenesis of the vascular lesions revealed by genetic studies.
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