高磷酸化
τ蛋白
Tau病理学
基因亚型
微管
神经科学
阿尔茨海默病
微管相关蛋白
神经纤维缠结
突变体
化学
老年斑
细胞生物学
陶氏病
纠纷
淀粉样蛋白(真菌学)
生物
病理
神经退行性变
磷酸化
疾病
生物化学
医学
基因
数学
纯数学
作者
Cathy A. Andorfer,Yvonne Kress,Marisol Espinoza,Rohan de Silva,Kerry L. Tucker,Yves‐Alain Barde,Karen Duff,Peter Davies
标识
DOI:10.1046/j.1471-4159.2003.01879.x
摘要
Neurofibrillary tangles are composed of insoluble aggregates of the microtubule-associated protein tau. In Alzheimer's disease the accumulation of neurofibrillary tangles occurs in the absence of tau mutations. Here we present mice that develop pathology from non-mutant human tau, in the absence of other exogenous factors, including beta-amyloid. The pathology in these mice is Alzheimer-like, with hyperphosphorylated tau accumulating as aggregated paired helical filaments. This pathologic tau accumulates in the cell bodies and dendrites of neurons in a spatiotemporally relevant distribution.
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