形态发生剂
生物
甲状腺激素受体
类固醇激素
维甲酸
受体
激素
超家族
核受体
内分泌学
功能(生物学)
细胞生物学
类固醇
甲状腺
计算生物学
遗传学
转录因子
基因
出处
期刊:Science
[American Association for the Advancement of Science]
日期:1988-05-13
卷期号:240 (4854): 889-895
被引量:7561
标识
DOI:10.1126/science.3283939
摘要
Analyses of steroid receptors are important for understanding molecular details of transcriptional control, as well as providing insight as to how an individual transacting factor contributes to cell identity and function. These studies have led to the identification of a superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid. Although animals employ complex and often distinct ways to control their physiology and development, the discovery of receptor-related molecules in a wide range of species suggests that mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.
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