Shell‐in‐Shell Microcapsules: A Novel Tool for Integrated, Spatially Confined Enzymatic Reactions

Angewandte Chemie International EditionVolume 46, Issue 29 p. 5605-5608 Communication Shell-in-Shell Microcapsules: A Novel Tool for Integrated, Spatially Confined Enzymatic Reactions† Oliver Kreft Dr., Oliver Kreft Dr. [email protected] Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Wissenschaftspark Golm, 14424 Potsdam, Germany, Fax: (+49) 331-567-9222Search for more papers by this authorMichelle Prevot Dr., Michelle Prevot Dr. Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Wissenschaftspark Golm, 14424 Potsdam, Germany, Fax: (+49) 331-567-9222Search for more papers by this authorHelmuth Möhwald Prof. Dr., Helmuth Möhwald Prof. Dr. Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Wissenschaftspark Golm, 14424 Potsdam, Germany, Fax: (+49) 331-567-9222Search for more papers by this authorGleb B. Sukhorukov Prof. Dr., Gleb B. Sukhorukov Prof. Dr. Department of Materials, Queen Mary University of London, Mile End Road, E1 4NS, London, UKSearch for more papers by this author Oliver Kreft Dr., Oliver Kreft Dr. [email protected] Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Wissenschaftspark Golm, 14424 Potsdam, Germany, Fax: (+49) 331-567-9222Search for more papers by this authorMichelle Prevot Dr., Michelle Prevot Dr. Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Wissenschaftspark Golm, 14424 Potsdam, Germany, Fax: (+49) 331-567-9222Search for more papers by this authorHelmuth Möhwald Prof. Dr., Helmuth Möhwald Prof. Dr. Max-Planck-Institut für Kolloid- und Grenzflächenforschung, Wissenschaftspark Golm, 14424 Potsdam, Germany, Fax: (+49) 331-567-9222Search for more papers by this authorGleb B. Sukhorukov Prof. Dr., Gleb B. Sukhorukov Prof. Dr. Department of Materials, Queen Mary University of London, Mile End Road, E1 4NS, London, UKSearch for more papers by this author First published: 05 July 2007 https://doi.org/10.1002/anie.200701173Citations: 268 † The support by the Volkswagen Foundation (I/80 051-054) and the 6th FP EU projects STREP-NMP3-CT-2005-516922 "SelectNANO" and STREP-001428 "Nanocaps" is kindly acknowledged. We are grateful to Radostina Georgieva for fruitful discussions and to Jürgen Hartmann for assistance with SEM measurements. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract The Matryoshka theory: This unique type of shell-in-shell microcapsule facilitates the stable spatial separation of biopolymers (enzymes) within distinct compartments of a single capsule entity. Architecture and wall properties of this system allow for the concerted action of enzymes from separate capsule compartments by metabolite diffusion across a semipermeable, intersecting polyelectrolyte membrane. References 1K. Kataoka, A. Harada, Y. Nagasaki, Adv. Drug Delivery Rev. 2001, 47, 113. 2V. P. Torchilin, Cell. Mol. Life Sci. 2004, 61, 2549. 3P. Gupta, K. Vermani, S. Garg, Drug Discovery Today 2002, 7, 569. 4Y. Qiu, K. Park, Adv. Drug Delivery Rev. 2001, 53, 321. 5A. Kikuchi, T. Okano, Adv. Drug Delivery Rev. 2002, 54, 53. 6H. H. Tonnesen, J. Karlsen, Drug Dev. Ind. Pharm. 2002, 28, 621. 7C. S. Peyratout, L. Dähne, Angew. Chem. 2004, 116, 3850; Angew. Chem. Int. Ed. 2004, 43, 3762 8A. G. Skirtach, O. Kreft, Stimuli-Sensitive Nanotechnology for Drug Delivery (Eds.: M. M. de Villiers, P. Aramwit, G. S. Kwon), in Biotechnology: Pharmaceutical Aspects Series, Vol. 6, AAPS Press, Virginia, USA, in press . 9A. F. Thünemann, S. Kubowicz, H. von Berlepsch, H. Möhwald, Langmuir 2006, 22, 2506. 10K. J. Pekarek, J. S. Jacob, E. Mathiowitz, Nature 1994, 367, 258. 11P. Y. Bolinger, D. Stamou, H. Vogel, J. Am. Chem. Soc. 2004, 126, 8594. 12Z. F. Dai, L. Dähne, H. Möhwald, B. Tiersch, Angew. Chem. 2002, 114, 4191; Angew. Chem. Int. Ed. 2002, 41, 4019. 13G. Decher, Science 1997, 277, 1232. 14E. Donath, G. B. Sukhorukov, F. Caruso, S. A. Davis, H. Möhwald, Angew. Chem. 1998, 110, 2323; Angew. Chem. Int. Ed. 1998, 37, 2201. 15G. B. Sukhorukov, E. Donath, S. Davis, H. Lichtenfeld, F. Caruso, V. I. Popov, H. Möhwald, Polym. Adv. Technol. 1998, 9, 759. 16D. V. Volodkin, N. I. Larionova, G. B. Sukhorukov, Biomacromolecules 2004, 5, 1962. 17C. Y. Wang, C. Y. He, Z. Tong, X. X. Liu, B. Y. Ren, F. Zeng, Int. J. Pharm. 2006, 308, 160. 18B. G. De Geest, R. E. Vandenbroucke, A. M. Guenther, G. B. Sukhorukov, W. E. Hennink, N. N. Sanders, J. Demeester, S. C. De Smedt, Adv. Mater. 2006, 18, 1005. 19J. Q. Brown, M. J. McShane, IEEE Sens. J. 2005, 5, 1197. 20O. Kreft, R. Georgieva, H. Bäumler, M. Steup, B. Müller-Röber, G. B. Sukhorukov, H. Möhwald, Macromol. Rapid Commun. 2006, 27, 435. 21O. P. Tiourina, A. A. Antipov, G. B. Sukhorukov, N. L. Larionova, Y. Lvov, H. Möhwald, Macromol. Biosci. 2001, 1, 209. 22Y. Lvov, A. A. Antipov, A. Mamedov, H. Möhwald, G. B. Sukhorukov, Nano Lett. 2001, 1, 125. 23Z. H. Lu, M. D. Prouty, Z. H. Guo, V. O. Golub, C. Kumar, Y. M. Lvov, Langmuir 2005, 21, 2042. 24A. I. Petrov, D. V. Volodkin, G. B. Sukhorukov, Biotechnol. Prog. 2005, 21, 918. 25D. V. Andreeva, D. A. Gorin, D. G. Shchukin, G. B. Sukhorukov, Macromol. Rapid Commun. 2006, 27, 931. 26D. V. Volodkin, A. I. Petrov, M. Prevot, G. B. Sukhorukov, Langmuir 2004, 20, 3398. 27N. G. Balabushevich, O. P. Tiourina, D. V. Volodkin, N. I. Larionova, G. B. Sukhorukov, Biomacromolecules 2003, 4, 1191. 28B. G. De Geest, A. G. Skirtach, T. R. M. De Beer, G. B. Sukhorukov, L. Bracke, W. R. G. Baeyens, J. Demeester, S. C. De Smedt, Macromol. Rapid Commun. 2007, 28, 88. 29D. G. Shchukin, D. A. Gorin, H. Möhwald, Langmuir 2006, 22, 7400. 30A. G. Skirtach, A. M. Javier, O. Kreft, K. Köhler, A. P. Alberola, H. Möhwald, W. J. Parak, G. B. Sukhorukov, Angew. Chem. 2006, 118, 4728; Angew. Chem. Int. Ed. 2006, 45, 4612. 31A. G. Skirtach, C. Dejugnat, D. Braun, A. S. Susha, A. L. Rogach, W. J. Parak, H. Möhwald, G. B. Sukhorukov, Nano Lett. 2005, 5, 1371. 32A. A. Antipov, G. B. Sukhorukov, Y. A. Fedutik, J. Hartmann, M. Giersig, H. Möhwald, Langmuir 2002, 18, 6687. 33K. Itano, J. Y. Choi, M. F. Rubner, Macromolecules 2005, 38, 3450. 34T. Mauser, C. Dejugnat, H. Möhwald, G. B. Sukhorukov, Langmuir 2006, 22, 5888. 35Z. J. Sui, J. B. Schlenoff, Langmuir 2004, 20, 6026. 36R. P. Haugland, Handbook of Fluorescent Probes and Research Biochemicals, Molecular Probes, Eugene, 2004. 37G. B. Sukhorukov, D. V. Volodkin, A. M. Günther, A. I. Petrov, D. B. Shenoy, H. Möhwald, J. Mater. Chem. 2004, 14, 2073. Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701173_s.html or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume46, Issue29July 16, 2007Pages 5605-5608 ReferencesRelatedInformation