Vagus nerve stimulation increases norepinephrine concentration and the gene expression of BDNF and bFGF in the rat brain

迷走神经电刺激 神经生长因子 神经营养因子 内科学 刺激 内分泌学 去甲肾上腺素 迷走神经 神经营养素 脑源性神经营养因子 神经化学 海马体 神经科学 医学 多巴胺 生物 受体
作者
Paolo Follesa,Francesca Biggio,Giorgio Gorini,Stefania Caria,Giuseppe Talani,Laura Dazzi,Monica Puligheddu,Francesco Marrosu,Giovanni Biggio
出处
期刊:Brain Research [Elsevier]
卷期号:1179: 28-34 被引量:309
标识
DOI:10.1016/j.brainres.2007.08.045
摘要

Vagus nerve stimulation therapy, effective for treatment-resistant epilepsy, has recently been approved also for treatment-resistant depression; nevertheless, the molecular mechanism(s) underlying its therapeutic action remains unclear. Given that neurotrophic factors and monoamines could play a crucial role in the pathophysiology of depression, we tested whether vagus nerve stimulation increases the expression of brain-derived neurotrophic factor, fibroblast growth factor, and nerve growth factor as well as the concentration of norepinephrine in the rat brain. Rats were implanted with a vagus nerve stimulator device and the effects of acute stimulation were evaluated on the growth factors mRNA levels and norepinephrine concentration by ribonuclease protection assay and microdialysis, respectively. We found that acute vagus nerve stimulation increased the expression of brain-derived neurotrophic factor and fibroblast growth factor in the hippocampus and cerebral cortex, decreased the abundance of nerve growth factor mRNA in the hippocampus, and, similar to the antidepressant drug venlafaxine, increased the norepinephrine concentration in the prefrontal cortex. This study demonstrates that acute vagus nerve stimulation triggers neurochemical and molecular changes in the rat brain involving neurotransmitters and growth factors known to play a crucial role in neuronal trophism. These new findings contribute to the elucidation of the molecular mechanisms underlying the therapeutic actions of vagus nerve stimulation in both treatment-resistant depression and epilepsy.
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