Brain Imaging Biomarkers to Predict Relapse in Alcohol Addiction

The finding that various regions were associated with relapse and craving is consistent with the organization of the brain into functional networks comprising complex connections among multiple regions. It is notable that the regions with the strongest prediction for relapse (vmPFC/ACC and precuneus) are central nodes of the default mode network (DMN), which is involved with the processing of internal states (including selfmonitoring) and deactivated when engaging in various behavioral tasks or when responding to the environment 9 (Figure). Also, the ventral striatum, which is one of the main targets for