免疫球蛋白E
免疫系统
生产(经济)
生物
免疫学
抗体
宏观经济学
经济
作者
Lawren C. Wu,Ali A. Zarrin
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2014-03-14
卷期号:14 (4): 247-259
被引量:259
摘要
IgE not only provides protective immunity against helminth parasites but can also mediate the type I hypersensitivity reactions that contribute to the pathogenesis of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis. Despite the importance of IgE in immune biology and allergic pathogenesis, the cells and the pathways that produce and regulate IgE are poorly understood. In this Review, we summarize recent advances in our understanding of the production and the regulation of IgE in vivo, as revealed by studies in mice, and we discuss how these findings compare to what is known about human IgE biology.
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