已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Enhanced expression of BMP6 inhibits hepatic fibrosis in non-alcoholic fatty liver disease

脂肪肝 酒精性肝病 医学 疾病 内科学 纤维化 胃肠病学 病理 肝硬化
作者
Stephanie Arndt,Eva Wacker,Christoph Dorn,A. Koch,M Saugspier,Wolfgang E. Thasler,Arndt Hartmann,Anja‐Katrin Bosserhoff,Claus Hellerbrand
出处
期刊:Gut [BMJ]
卷期号:64 (6): 973-981 被引量:52
标识
DOI:10.1136/gutjnl-2014-306968
摘要

Objective

Bone morphogenetic protein 6 (BMP6) has been identified as crucial regulator of iron homeostasis. However, its further role in liver pathology including non-alcoholic fatty liver disease (NAFLD) and its advanced form non-alcoholic steatohepatitis (NASH) is elusive. The aim of this study was to investigate the expression and function of BMP6 in chronic liver disease.

Design

BMP6 was analysed in hepatic samples from murine models of chronic liver injury and patients with chronic liver diseases. Furthermore, a tissue microarray comprising 110 human liver tissues with different degree of steatosis and inflammation was assessed. BMP6-deficient (BMP6−/−) and wild-type mice were compared in two dietary NASH-models, that is, methionine choline-deficient (MCD) and high-fat (HF) diets.

Results

BMP6 was solely upregulated in NAFLD but not in other murine liver injury models or diseased human livers. In NAFLD, BMP6 expression correlated with hepatic steatosis but not with inflammation or hepatocellular damage. Also, in vitro cellular lipid accumulation in primary human hepatocytes induced increased BMP6 expression. MCD and HF diets caused more hepatic inflammation and fibrosis in BMP6−/− compared with wild-type mice. However, only in the MCD and not in the HF diet model BMP6−/− mice developed marked hepatic iron overload, suggesting that further mechanisms are responsible for protective BMP6 effect. In vitro analysis revealed that recombinant BMP6 inhibited the activation of hepatic stellate cells (HSCs) and reduced proinflammatory and profibrogenic gene expression in already activated HSCs.

Conclusions

Steatosis-induced upregulation of BMP6 in NAFLD is hepatoprotective. Induction of BMP6-signalling may be a promising antifibrogenic strategy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
不攻自破发布了新的文献求助10
刚刚
搜集达人应助gxmu6322采纳,获得10
2秒前
xiuxiuzhang完成签到 ,获得积分10
3秒前
Leo发布了新的文献求助10
4秒前
努力搞科研完成签到,获得积分10
6秒前
隐形曼青应助不攻自破采纳,获得10
9秒前
10秒前
10秒前
12秒前
胡壮壮发布了新的文献求助10
16秒前
sidneyyang完成签到,获得积分10
19秒前
21秒前
22秒前
24秒前
24秒前
灰鸽舞完成签到 ,获得积分10
25秒前
sybil发布了新的文献求助10
26秒前
缓慢珠发布了新的文献求助10
26秒前
华仔应助bukeshuo采纳,获得30
27秒前
霸气的亿先完成签到 ,获得积分10
27秒前
小小科研人完成签到,获得积分10
28秒前
28秒前
31秒前
纪富完成签到,获得积分10
32秒前
缓慢珠完成签到,获得积分10
35秒前
万能图书馆应助lan采纳,获得10
35秒前
顾矜应助小小科研人采纳,获得10
39秒前
42秒前
42秒前
eth完成签到 ,获得积分10
42秒前
45秒前
bukeshuo发布了新的文献求助30
47秒前
科目三应助sidneyyang采纳,获得10
49秒前
Xuxiaojun完成签到,获得积分20
52秒前
52秒前
CHEN完成签到 ,获得积分10
52秒前
55秒前
伊笙完成签到 ,获得积分10
56秒前
小蘑菇应助菜狗采纳,获得10
56秒前
1分钟前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Gerard de Lairesse : an artist between stage and studio 500
Digging and Dealing in Eighteenth-Century Rome 500
Queer Politics in Times of New Authoritarianisms: Popular Culture in South Asia 500
Livre et militantisme : La Cité éditeur 1958-1967 500
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3062928
求助须知:如何正确求助?哪些是违规求助? 2717865
关于积分的说明 7456379
捐赠科研通 2364095
什么是DOI,文献DOI怎么找? 1253222
科研通“疑难数据库(出版商)”最低求助积分说明 608474
版权声明 596552