氟西汀
5-羟色胺能
行为绝望测验
5-羟色胺再摄取抑制剂
海马结构
海马体
内分泌学
血清素
梨状皮质
内科学
神经科学
心理学
化学
医学
抗抑郁药
受体
作者
Dong-Pyo Jang,So Hee Lee,Chan-Woong Park,Sang Yoon Lee,Young-Bo Kim,Zang-Hee Cho
标识
DOI:10.1016/j.neulet.2008.12.024
摘要
We used the [F-18]FDG micro-PET neuroimaging to examine the effects of fluoxetine on brain activity in rats and on their behavioral response in the forced swimming test (FST). In the first experiment, the rats were administered doses of fluoxetine (10 or 20 mg/kg) 24, 19 and 1 h before the rat brains were scanned. Fluoxetine induced strong activation of the dorsal hippocampus and the deactivation of the inferior colliculus, medulla oblongata, and prelimbic cortex in a dose-dependent manner. These results seemed to be related with the changes in 5-HT (5-hydroxytryptamine, serotonin) levels after selective serotonin reuptake-inhibitor treatments. In the second experiment, the changes in glucose metabolism in the test session were measured after fluoxetine was given between pre-test and test sessions of the FST. Fluoxetine administration significantly decreased immobility behavior compared with saline administration. At the same time, the activity of the insular/piriform cortex decreased significantly. In contrast, the extent of cerebellar activation increased. The glucose metabolism of the dorsal hippocampus also increased, which suggests that post-stress changes in the facilitation of hippocampal serotonergic neurotransmission lead to decreased immobilization in the FST.
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