生物
基因组
遗传学
黑腹果蝇
基因组计划
常染色质
全基因组测序
秀丽隐杆线虫
计算生物学
基因
染色体
异染色质
作者
Mark D. Adams,S Celniker,Robert A. Holt,Cheryl Evans,Jeannine D. Gocayne,Peter G. Amanatides,Steven E. Scherer,Peter W. Li,Roger A. Hoskins,Richard F. Galle,Reed George,Suzanna Lewis,Stephen M. Richards,Michael Ashburner,Scott N. Henderson,Granger G. Sutton,Jennifer R. Wortman,Mark Yandell,Qing Zhang,Lin X. Chen
出处
期刊:Science
[American Association for the Advancement of Science]
日期:2000-03-24
卷期号:287 (5461): 2185-2195
被引量:5953
标识
DOI:10.1126/science.287.5461.2185
摘要
The fly Drosophila melanogaster is one of the most intensively studied organisms in biology and serves as a model system for the investigation of many developmental and cellular processes common to higher eukaryotes, including humans. We have determined the nucleotide sequence of nearly all of the approximately 120-megabase euchromatic portion of the Drosophila genome using a whole-genome shotgun sequencing strategy supported by extensive clone-based sequence and a high-quality bacterial artificial chromosome physical map. Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation. The genome encodes approximately 13,600 genes, somewhat fewer than the smaller Caenorhabditis elegans genome, but with comparable functional diversity.
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