先天免疫系统
生物
免疫
吞噬作用
体液免疫
免疫系统
抗菌肽
获得性免疫系统
免疫学
模式识别受体
效应器
抗菌剂
细胞生物学
微生物学
作者
Michel Salzet,Aurélie Tasiemski,Edwin L. Cooper
标识
DOI:10.2174/138161206777947551
摘要
Innate immunity plays a major role as a first defense against microbes. Effectors of the innate response include pattern recognition receptors (PRR), phagocytic cells, proteolytic cascades and peptides/proteins with antimicrobial properties. Each element of these events has been well studied in vertebrates and in some invertebrates such as annelids. From these different researches, it appears that mammalian innate immunity could be considered as a mosaic of invertebrate immune responses. Annelids belonging to the lophotrochozoans group are primitive coelomates that possess specially developed cellular immunity against pathogens including phagocytosis, encapsulation and spontaneous cytotoxicity of coelomocytes against allogenic or xenogenic cells. They have also developed an important humoral immunity that is based on antimicrobial, hemolytic and clotting properties of their body fluid. In the present review, we will emphasize the different immunodefense strategies that adaptation has taken during the course of evolution of two classes of annelids i.e. oligochaetes and achaetes. Keywords: CD markers, coelomic cytolytic factor (CCF), Antimicrobial Peptides, Cytokines, Serine Protease Inhibitors
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