Androgen Receptor Expression Relationship with Semen Variables in Infertile Men with Varicocele

No AccessJournal of UrologyAdult Urology1 Jun 2013Androgen Receptor Expression Relationship with Semen Variables in Infertile Men with Varicocele Adel A. Zalata, Naglaa Mokhtar, Abd El-Naser Badawy, Gamal Othman, Moheiddin Alghobary, and Taymour Mostafa Adel A. ZalataAdel A. Zalata Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt , Naglaa MokhtarNaglaa Mokhtar Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt , Abd El-Naser BadawyAbd El-Naser Badawy Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt , Gamal OthmanGamal Othman Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt , Moheiddin AlghobaryMoheiddin Alghobary Dermatology, Venereology and Andrology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt , and Taymour MostafaTaymour Mostafa Andrology and Sexology Department, Faculty of Medicine, Cairo University, Cairo, Egypt View All Author Informationhttps://doi.org/10.1016/j.juro.2012.11.112AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Androgen receptor, a member of the nuclear receptor superfamily, has important roles in male reproductive function. It is required for sexual differentiation, pubertal development, spermatogenesis regulation, meiosis completion and spermatocyte transition to haploid round spermatids. We assessed the association of androgen receptor expression and semen variables in infertile men with varicocele. Materials and Methods: A total of 299 men were grouped into healthy, fertile controls, infertile men without varicocele and men with infertility associated with varicocele. A history was obtained, clinical examination and semen analysis were done and reproductive hormones were estimated. Androgen receptor expression and the acrosome reaction were determined in recovered spermatozoa. Results: Androgen receptor expression was significantly decreased in infertile men with varicocele more than in infertile men without varicocele compared to fertile controls. Androgen receptor correlated positively with sperm count, motility, normal forms, velocity, linear velocity, acrosome reaction and α-glucosidase. It correlated negatively with serum follicle-stimulating hormone and estradiol. Multiple stepwise regression analysis of androgen receptor expression revealed that the sperm acrosome reaction and linearity index were the most affected independent variables. Conclusions: Androgen receptor expression was significantly decreased in infertile men with varicocele more than in infertile men without varicocele compared to fertile men. Androgen receptor expression correlated positively with sperm count, motility, normal forms, velocity, linear velocity and acrosome reaction. References 1 : Novel mutation in the transactivation-regulating domain of the androgen receptor in a patient with azoospermia. J Androl2011; 32: 367. Google Scholar 2 : Oligozoospermia with normal fertility in male mice lacking the androgen receptor in testis peritubular myoid cells. Proc Natl Acad Sci U S A2006; 103: 17718. 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Zalata Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt More articles by this author Naglaa Mokhtar Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt More articles by this author Abd El-Naser Badawy Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt More articles by this author Gamal Othman Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt More articles by this author Moheiddin Alghobary Dermatology, Venereology and Andrology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt More articles by this author Taymour Mostafa Andrology and Sexology Department, Faculty of Medicine, Cairo University, Cairo, Egypt More articles by this author Expand All Advertisement PDF downloadLoading ...