内皮功能障碍
伊诺斯
内皮干细胞
一氧化氮
糖尿病
脐静脉
血管内皮生长因子
血管生成
血管舒张
蛋白激酶B
作者
Lei Shen,Ian M. Evans,Domingos S. R. Souza,Mats Dreifaldt,Michael R. Dashwood,Mohamed-Ali Vidya
出处
期刊:Current Vascular Pharmacology
[Bentham Science]
日期:2016-02-29
卷期号:14 (2): 168-174
被引量:10
标识
DOI:10.2174/1570161114666151202210128
摘要
Adipose tissue (AT) is now widely accepted as a key secretary organ, as well as an energy storage depot. It secretes a series of cytokines, hormones and bioactive molecules: adipokines. Adiponectin is an abundant systemic adipokine that uniquely is reduced in obesity and increases on weight loss, is anti-inflammatory, promotes insulin sensitivity and affords cardiometabolic protection. It was considered a true adipokine, in that it is exclusively generated by the adipocytes of the adipose tissue. However, recent evidence points to it being secreted by a range of other organs. This review summarizes the non-adipose sources of adiponectin especially that derived from the endothelium, its vasoprotective role and intracellular signalling pathways. Endothelium derived adiponectin may potentially be a new target for clinical intervention in cardiovascular disease.
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