化学
扁桃酸
酰胺
烟草花叶病毒
吡唑
生物测定
生物活性
结构-活动关系
立体化学
有机化学
病毒
生物化学
体外
病毒学
遗传学
生物
作者
Yan Xie,Ruan Xianghui,Gong Huayu,Yihui Wang,Xiao Wang,Ju Zhang,Qin Li
摘要
A series of novel mandelic acid pyrazole amide compounds were synthesized and characterized. Moreover, their antiviral activities against tobacco mosaic virus were evaluated. The bioassay results indicated that as-prepared compounds showed antiviral activity against tobacco mosaic virus at a concentration of 500 g/mL. The curative activity of compound 4g is 59.5%, which was comparable with positive control (Ningnanmycin, 61.0%). The inactivation activity of the compound 4l exhibited 80.1%, which was higher than that of Ningnanmycin (75.0%), and its protective activity was 88.7%, which is comparable with that of Ningnanmycin (90.7%).
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