数量结构-活动关系
丙戊酸
芳基
对接(动物)
化学
HDAC8型
立体化学
组合化学
药理学
医学
生物化学
有机化学
乙酰化
癫痫
精神科
烷基
护理部
基因
组蛋白H2A
作者
Heidy Martínez-Pacheco,Guillermo Ramírez-Galicia,Midalia Vergara-Arias,Jürg Gertsch,Jonathan Fragoso-Vázquez,David Méndez-Luna,Ana Lúcia Abujamra,Cabrera-Perez Laura Cristina,Rosales-Hernandez Martha Cecilia,Irene Mendoza-Lujambio,José Correa‐Basurto
出处
期刊:Anti-cancer Agents in Medicinal Chemistry
[Bentham Science]
日期:2017-06-19
卷期号:17 (7)
被引量:4
标识
DOI:10.2174/1871520616666161019143219
摘要
Background: Histone deacetylase 8 (HDAC8) is a plausible target for the development of novel anticancer drugs using a metal-chelating group and hydrophobic moieties as pharmacophores. It is known that valproic acid (administered as its salt, sodium valproate; VPANa+) is an HDAC8 inhibitor characterized by its hydrophobic chains. Nevertheless, VPA is hepatotoxic and VPA analogues might be explored for less hepatotoxic antiproliferative compounds. Keywords: Docking studies, QSAR studies, Artificial Neuron Network, Anticancer test, 2D-BCUT descriptors, derivatives.
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