Perioperative management and outcomes of esophageal atresia and tracheoesophageal fistula

医学 气管食管瘘 闭锁 吻合 回顾性队列研究 队列 围手术期 瘘管 儿科 外科 内科学
作者
Dave R. Lal,Samir K. Gadepalli,Cynthia D. Downard,Daniel J. Ostlie,Peter C. Minneci,Ruth M. Swedler,Thomas Chelius,Laura D. Cassidy,Cooper T. Rapp,Katherine J. Deans,Mary E. Fallat,S. Maria E. Finnell,Michael A. Helmrath,Ronald B. Hirschl,Rashmi Kabre,Charles M. Leys,Grace Z. Mak,Jessica Raque,Frederick J. Rescorla,Jacqueline M. Saito,Shawn D. St. Peter,Daniel von Allmen,Brad W. Warner,Thomas T. Sato
出处
期刊:Journal of Pediatric Surgery [Elsevier BV]
卷期号:52 (8): 1245-1251 被引量:151
标识
DOI:10.1016/j.jpedsurg.2016.11.046
摘要

Background/Purpose Esophageal atresia/tracheoesophageal fistula (EA/TEF) is a rare congenital anomaly lacking contemporary data detailing patient demographics, medical/surgical management and outcomes. Substantial variation in the care of infants with EA/TEF may affect both short- and long-term outcomes. The purpose of this study was to characterize the demographics, management strategies and outcomes in a contemporary multi-institutional cohort of infants diagnosed with EA/TEF to identify potential areas for standardization of care. Methods A multi-institutional retrospective cohort study of infants with EA/TEF treated at 11 children's hospitals between 2009 and 2014 was performed. Over the 5 year period, 396 cases were identified in the 11 centers (7 ± 5 per center per year). All infants with a diagnosis of EA/TEF made within 30 days of life who had surgical repair of their defect defined as esophageal reconstruction with or without ligation of TEF within the first six months of life were included. Demographic, operative, and outcome data were collected and analyzed to detect associations between variables. Results Prenatal suspicion or diagnosis of EA/TEF was present in 53 (13%). The most common anatomy was proximal EA with distal TEF (n = 335; 85%) followed by pure EA (n = 27; 7%). Clinically significant congenital heart disease (CHD) was present in 137 (35%). Mortality was 7.5% and significantly associated with CHD (p < 0.0001). Postoperative morbidity occurred in 62% of the population, including 165 (42%) cases with anastomotic stricture requiring intervention, anastomotic leak in 89 (23%), vocal cord paresis/paralysis in 26 (7%), recurrent fistula in 19 (5%), and anastomotic dehiscence in 9 (2%). Substantial variation in practice across our institutions existed: bronchoscopy prior to repair was performed in 64% of cases (range: 0%–100%); proximal pouch contrast study in 21% (0%–69%); use of interposing material between the esophageal and tracheal suture lines in 38% (0%–69%); perioperative antibiotics ≥24 h in 69% (36%–97%); and transanastomotic tubes in 73% (21%–100%). Conclusion Contemporary treatment of EA/TEF is characterized by substantial variation in perioperative management and considerable postoperative morbidity and mortality. Future studies are planned to establish best practices and clinical care guidelines for infants with EA/TEF. Level of Evidence Type of study: Treatment study. Level IV.
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