化学
分析物
微流控
流体学
电极
极化(电化学)
电泳
离子
电场
分析化学(期刊)
浓差极化
电压
法拉第电流
法拉第效率
纳米技术
电化学
光电子学
色谱法
电极电位
材料科学
航空航天工程
膜
生物化学
有机化学
物理化学
工程类
物理
量子力学
作者
Xiang Li,Long Luo,Richard M. Crooks
标识
DOI:10.1021/acs.analchem.7b00365
摘要
We describe the design and characteristics of a paper-based analytical device for analyte concentration enrichment. The device, called a hybrid paper-based analytical device (hyPAD), uses faradaic electrochemistry to create an ion depletion zone (IDZ), and hence a local electric field, within a nitrocellulose flow channel. Charged analytes are concentrated near the IDZ when their electrophoretic and electroosmotic velocities balance. This process is called faradaic ion concentration polarization. The hyPAD is simple to construct and uses only low-cost materials. The hyPAD can be tuned for optimal performance by adjusting the applied voltage or changing the electrode design. Moreover, the throughput of hyPAD is 2 orders of magnitude higher than that of conventional, micron-scale microfluidic devices. The hyPAD is able to concentrate a range of analytes, including small molecules, DNA, proteins, and nanoparticles, in the range of 200-500-fold within 5 min.
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