Combined Effect of Systemic Bisphosphonates, Calcium and Vitamin D on Alveolar bone in Osteoporotic Postmenopausal Females having Chronic Periodontitis Following Surgical Periodontal Therapy

This study was conducted to evaluate the systemic use of Alendronate (ALN), an aminobisphosphonate in combination with calcium and vitamin D supplementations on the alveolar bone in osteoporotic postmenopausal females following surgical periodontal treatment of chronic periodontitis. Subjects and Methods: Forty postmenopausal osteoporotic females having chronic periodontitis were divided into two groups. Group (1) which is the control group (n=20) received systemic ALN for 6 months. To group (2) which is the study group (n=20) systemic ALN was given in combination with calcium and vitamin D for 6 months. Initial therapy including scaling, root planning and oral hygiene instructions followed by surgical periodontal therapy using the modified Widman flap procedures was performed. The pocket depth (PD) and clinical attachment level (CAL) in addition to radiographic linear, density and angular defect measurements were done at baseline before starting the initial therapy and at 6 months postoperatively. The results revealed a significant gain in clinical attachment level and reduction of pocket depth in both groups with presence of a significant improvement of all the radiographic measurements at the end of the study period. The study group always showed higher percentages of improvement than the control group in all the measurements. It can be concluded that systemic ALN in combination with calcium and vitamin D administration to postmenopausal osteoporotic females is a valuable treatment modality in adjunct to surgical therapy in the management of chronic periodontitis. (Basma Mostafa, Ebtehal Hamdy, Nermeen Nasif. Combined Effect of Systemic Bisphosphonates, Calcium and Vitamin D on Alveolar bone in Osteoporotic Postmenopausal Females having Chronic Periodontitis Following Surgical Periodontal Therapy. L Sci J. 2012; 9 (3):613-622) (ISSN: 1097- 8135). http://www.lifesciencesite.com 86