白细胞介素33
促炎细胞因子
免疫学
肥大细胞
先天免疫系统
白细胞介素5
肿瘤坏死因子α
获得性免疫系统
先天性淋巴细胞
生物
免疫系统
白细胞介素
细胞生物学
炎症
细胞因子
作者
Stefano Tetè,Andrea Saggini,Giulio Maccauro,Marco Rosati,Francesca Conti,Ettore Cianchetti,Domenico Tripodi,Elena Toniato,Mario Fulcheri,Vincenzo Salini,A. Caraffa,P. Antinolfi,S. Frydas,Franco Pandolfi,Paolo Conti,G. Potalivo,Mauro Nicoletti,Theoharides Tc
出处
期刊:PubMed
日期:2012-10-05
卷期号:26 (3): 319-26
被引量:24
摘要
Mast cells are granulated hematopoietic cells derived from stem cells that reside in nearly all tissues and are involved in protection of a host from bacterial infection with a protective and pathogenic activity. Mast cells are important for both innate and adaptive immunity in tissues which are in close contact with the environment. These cells express proinflammatory cytokines such as IL-1, IL-6, IL-8 and tumor necrosis factor which are necessary for innate immunity. Mast cells also produce interleukin-9 and enhance mast cell expression of several cytokines including IL-1beta, IL-5, IL-6, IL-9 and IL-13. In addition, IL-9 can induce mast cell production of TGF-beta which can have proinflammatory downstream effects. IL-9 can function as either a positive or a negative regulator of immune responses and can have a detrimental role in allergy and autoimmunity. Furthermore, IL-9 contributes to disease by promoting mast cell expansion and production of IL-13 which in turn contributes to airway hyperresponsiveness. Here, in this editorial we review the interrelationship between IL-9 and mast cells.
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