表面改性
材料科学
聚氨酯
肝素
生物分子
粘附
肽
聚合物
血小板
体外
生物医学工程
生物物理学
高分子化学
纳米技术
化学工程
生物化学
化学
复合材料
免疫学
工程类
生物
医学
作者
Jun Fang,Jialing Zhang,Jun Du,Yanjun Pan,Jiyun Shi,Yongxuan Peng,Wei-Ming Chen,Yuan Liu,Sang‐Ho Ye,William R. Wagner,Meng Yin,Xiumei Mo
标识
DOI:10.1021/acsami.6b04289
摘要
Surface coimmobilization modifications of blood-contacting devices with both antithrombogenic moieties and endothelium-inducing biomolecules may create a synergistic effect to improve their performance. However, it is difficult to perform covalent dual-functionalization with both biomolecules on the surface of normally used synthetic polymeric substrates. Herein, we developed and characterized an orthogonally functionalizable polymer, biodegradable elastic poly(ester urethane)urea with disulfide and amino groups (PUSN), which was further fabricated into electropun fibrous scaffolds and surface modified with heparin and endothelial progenitor cells (EPC) recruiting peptide (TPS). The modification effects were assessed through platelet adhesion, EPC, and HUVEC proliferation. Results showed the dual modified PUSN scaffolds demonstrated a synergistic effect of reduced platelet deposition and improved EPC proliferation in vitro study, and demonstrated their potential application in small diameter vascular regeneration.
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