铑
化学
催化作用
醇脱氢酶
牛血清白蛋白
介孔材料
转移加氢
介孔有机硅
联吡啶
酒
组合化学
有机化学
高分子化学
介孔二氧化硅
色谱法
钌
晶体结构
作者
Tomoki Himiyama,Minoru Waki,Yoshifumi Maegawa,Shinji Inagaki
标识
DOI:10.1002/anie.201904116
摘要
Abstract The combined use of a metal‐complex catalyst and an enzyme is attractive, but typically results in mutual inactivation. A rhodium (Rh) complex immobilized in a bipyridine‐based periodic mesoporous organosilica (BPy‐PMO) shows high catalytic activity during transfer hydrogenation, even in the presence of bovine serum albumin (BSA), while a homogeneous Rh complex exhibits reduced activity due to direct interaction with BSA. The use of a smaller protein or an amino acid revealed a clear size‐sieving effect of the BPy‐PMO that protected the Rh catalyst from direct interactions. A combination of Rh‐immobilized BPy‐PMO and an enzyme (horse liver alcohol dehydrogenase; HLADH) promoted sequential reactions involving the transfer hydrogenation of NAD + to give NADH followed by the asymmetric hydrogenation of 4‐phenyl‐2‐butanone with high enantioselectivity. The use of BPy‐PMO as a support for metal complexes could be applied to other systems consisting of a metal‐complex catalyst and an enzyme.
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