Hypoglycemic effects of polysaccharides from corn silk (Maydis stigma) and their beneficial roles via regulating the PI3K/Akt signaling pathway in L6 skeletal muscle myotubes

PI3K/AKT/mTOR通路 过剩4 多糖 蛋白激酶B 化学 骨骼肌 葡萄糖转运蛋白 功能性食品 葡萄糖摄取 细胞生物学 生物化学 药理学 信号转导 内科学 内分泌学 生物 食品科学 医学 胰岛素
作者
Qingwen Guo,Zhongqin Chen,Ramesh Kumar Santhanam,Leilei Xu,Xudong Gao,Qiqi Ma,Zihan Xue,Hạixia Chen
出处
期刊:International Journal of Biological Macromolecules [Elsevier]
卷期号:121: 981-988 被引量:77
标识
DOI:10.1016/j.ijbiomac.2018.10.100
摘要

In the present study, the physicochemical properties of polysaccharides from corn silk (CSP) with different molecular weights were characterized and their inhibitory actions against α-glucosidase and α-amylase were evaluated. Then their effects on glucose uptake and mechanism of action in PI3K/Akt signaling pathway were also determined in L6 skeletal muscle cells. Results demonstrated that CSP could significantly inhibit α-amylase and α-glucosidase. CSP were non-toxic and they considerably increased the 2-NBDG uptake (P < 0.05) in L6 cells. Additionally, CSP regulated the PI3K/Akt signaling pathway and promoted the translocation of GLUT4 to the plasma membrane that would enhanced the glucose uptake in rat L6 skeletal muscle cells. Among the tested polysaccharides, CSP2 with the molecular weight of 62.16 kDa exerted appreciable hypoglycemic activity. Altogether it was suggested that CSP could be the promising candidate in the treatment of Type 2 Diabetes Mellitus (T2DM). The elucidation of the potential anti-diabetic mechanism of the polysaccharides from corn silk will facilitate their utilization in the functional food industries.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
高高凡霜发布了新的文献求助10
刚刚
恬淡虚无完成签到,获得积分10
2秒前
芋曦完成签到,获得积分10
2秒前
杏仁儿完成签到,获得积分10
3秒前
柒柒完成签到,获得积分10
4秒前
4秒前
4秒前
caixia完成签到,获得积分10
4秒前
浅兮完成签到,获得积分20
6秒前
杏仁儿发布了新的文献求助10
6秒前
7秒前
烨枫晨曦完成签到,获得积分10
7秒前
unique发布了新的文献求助10
8秒前
争取不秃顶的医学僧完成签到,获得积分10
8秒前
8秒前
科研通AI5应助科研通管家采纳,获得10
9秒前
9秒前
lxd应助科研通管家采纳,获得20
9秒前
科研通AI5应助科研通管家采纳,获得10
9秒前
NexusExplorer应助科研通管家采纳,获得10
9秒前
大个应助科研通管家采纳,获得10
9秒前
李健应助科研通管家采纳,获得10
9秒前
小二郎应助科研通管家采纳,获得10
9秒前
深情安青应助科研通管家采纳,获得10
9秒前
xs应助科研通管家采纳,获得10
9秒前
彭于晏应助科研通管家采纳,获得10
9秒前
FashionBoy应助科研通管家采纳,获得10
9秒前
浅兮发布了新的文献求助10
9秒前
科研通AI5应助科研通管家采纳,获得10
9秒前
领导范儿应助科研通管家采纳,获得10
9秒前
Ava应助嘤嘤怪采纳,获得10
9秒前
思源应助科研通管家采纳,获得10
9秒前
彭于晏应助科研通管家采纳,获得10
9秒前
9秒前
CodeCraft应助科研通管家采纳,获得10
9秒前
10秒前
10秒前
酷波er应助科研通管家采纳,获得30
10秒前
10秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Structural Load Modelling and Combination for Performance and Safety Evaluation 1000
Conference Record, IAS Annual Meeting 1977 720
電気学会論文誌D(産業応用部門誌), 141 巻, 11 号 510
有源雷达散射截面减缩——理论与应用 赫玛·辛格,拉凯什·莫汉·杰哈 500
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3569308
求助须知:如何正确求助?哪些是违规求助? 3140626
关于积分的说明 9438650
捐赠科研通 2841729
什么是DOI,文献DOI怎么找? 1561819
邀请新用户注册赠送积分活动 730660
科研通“疑难数据库(出版商)”最低求助积分说明 718179