纳米笼
光热治疗
己内酯
热疗
材料科学
化学
纳米技术
聚合物
复合材料
有机化学
催化作用
共聚物
医学
内科学
作者
Ju Hyang Park,Hojun Seo,Da In Kim,Ji Hyun Choi,Jin Ho Son,Jongbok Kim,Geon Dae Moon,Dong Choon Hyun
出处
期刊:Pharmaceutics
[Multidisciplinary Digital Publishing Institute]
日期:2019-02-01
卷期号:11 (2): 60-60
被引量:16
标识
DOI:10.3390/pharmaceutics11020060
摘要
This paper introduces a new fibrous system for synergistic cancer therapy, which consists of gold nanocage (AuNC)-loaded poly(ε-caprolactone) (PCL) fibers with encapsulation of a chemotherapeutic anticancer drug in their core and loading of a phase-changeable fatty acid in their sheath. Under on⁻off switching of near-infrared (NIR) light irradiation, the excellent photothermal ability and photostability of AuNCs allows repeated, significant heating of the fibers to a temperature available to hyperthermia. Simultaneously, the NIR light-induced heat generation enables the melting out of the loaded fatty acid, leading to a rapid release of the drug molecules from the fibers. The combination of this NIR light-triggered drug release with the repeated hyperthermia treatment exhibits excellent anticancer efficacy.
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