材料科学
化学工程
介孔材料
介孔二氧化硅
药物输送
纳米颗粒
生物相容性
硅烷
硅酮
表面改性
丙烯酸
纳米技术
高分子化学
共聚物
有机化学
催化作用
复合材料
聚合物
化学
冶金
工程类
作者
Keju Zhang,Dong Zhou,Zhiguo Wang,Yuhong Zhang,Peixin He
出处
期刊:Nanotechnology
[IOP Publishing]
日期:2019-06-11
卷期号:30 (35): 355604-355604
被引量:13
标识
DOI:10.1088/1361-6528/ab209d
摘要
The synthesis of drug delivery systems based on surface-modified mesoporous silica hollow structures remains a huge challenge. In this paper, we have obtained hollow mesoporous silica nanoparticles (MSNs) by surfactant directed sol-gel assisted hydrothermal treatment. The MSNs have the inorganic-organic hybrid frameworks with uniform diameter distribution (260 nm), and their specific surface area, mesoporous size and pore volume are 540 m2 g-1, 3.7 nm, 0.58 cm3 g-1, respectively. It was proved that the preparation of hollow ethane-bridged nanospheres with two silicon source was due to the high crosslinking of the silicone interface and hydrothermal treatment, providing a new approach for the study of drug-loaded and controlled release behavior. Based on the synthesis of MSNs, MSNs were modified by methacryloxy propyl trimethoxyl silane (MPS) on the surface of MSNs. Then N-isopropylacryamide (NIPAM) and acrylic acid (AA) were grafted onto the surface of modified MSNs. The hollow ethane-bridged PNA-MSNs (poly (NIPAM-co-acrylic acid)-MSNs) with two silicon source were prepared successfully. Due to their distinctive hollow structure, PNA-MSNs demonstrated high drug encapsulation efficiency (70.4% ± 2.9%). The experiment results proved that the modified hollow nanoparticles not only had good biocompatibility and stability, but also possessed pH-/thermal-dual responsiveness in drug release.
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