抗菌剂
生物膜
化学
抗生素
抗生素耐药性
微生物学
细菌
多重耐药
纳米技术
生物
生物化学
遗传学
有机化学
材料科学
作者
Akash Gupta,Ryan F. Landis,Cheng‐Hsuan Li,Martin Schnurr,Riddha Das,Yi-Wei Lee,Mahdieh Yazdani,Yuanchang Liu,Anastasia Kozlova,Vincent M. Rotello
摘要
The rapid emergence of antibiotic-resistant bacterial "superbugs" with concomitant treatment failure and high mortality rates presents a severe threat to global health. The superbug risk is further exacerbated by chronic infections generated from antibiotic-resistant biofilms that render them refractory to available treatments. We hypothesized that efficient antimicrobial agents could be generated through careful engineering of hydrophobic and cationic domains in a synthetic semirigid polymer scaffold, mirroring and amplifying attributes of antimicrobial peptides. We report the creation of polymeric nanoparticles with highly efficient antimicrobial properties. These nanoparticles eradicate biofilms with low toxicity to mammalian cells and feature unprecedented therapeutic indices against red blood cells. Most notably, bacterial resistance toward these nanoparticles was not observed after 20 serial passages, in stark contrast to clinically relevant antibiotics where significant resistance occurred after only a few passages.
科研通智能强力驱动
Strongly Powered by AbleSci AI