立体中心
化学
芳基
区域选择性
催化作用
功能群
肟
铜
取代基
高分子化学
组合化学
有机化学
对映选择合成
聚合物
烷基
作者
Ming Li,Cui‐Tian Wang,Qiao-Fei Bao,Yi‐Feng Qiu,Wan‐Xu Wei,Xuesong Li,Yu‐Zhao Wang,Zhe Zhang,Jinlin Wang,Yong‐Min Liang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-01-21
卷期号:23 (3): 751-756
被引量:33
标识
DOI:10.1021/acs.orglett.0c03973
摘要
A copper-catalyzed radical cross-coupling of oxime esters and activated alkenes is accomplished for the synthesis of cyanoalkylsulfonylated oxindoles and cyanoalkyl amides via an aryl migration strategy. Specifically, the subsequent mechanism research indicates that the unique desulfonylation and sulfone addition processes were involved in the transformation. This transformation is identified as having good functional group applicability with two different quaternary stereocenter in a regioselective manner, which is controlled by the substituent group of the nitrogen.
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