骨髓纤维化
骨髓增生性疾病
髓系白血病
医学
髓样
骨髓增生性肿瘤
真性红细胞增多症
造血
免疫学
发病机制
急性白血病
炎症
白血病
癌症研究
生物
骨髓
干细胞
遗传学
作者
Douglas Tremblay,Abdulraheem Yacoub,Ronald Hoffman
标识
DOI:10.1016/j.hoc.2020.12.001
摘要
Myeloproliferative disorders are a group of diseases morphologically linked by terminal myeloid cell expansion that frequently evolve from one clinical phenotype to another and eventually progress to acute myeloid leukemia . Diagnostic criteria for the Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs) have been established by the World Health Organization and they are recognized as blood cancers. MPNs have a complex and incompletely understood pathogenesis that includes systemic inflammation, clonal hematopoiesis , and constitutive activation of the JAK-STAT pathway. Complications, such as thrombosis and progression to overt forms of myelofibrosis and acute leukemia , contribute significantly to morbidity and mortality of patients with MPN.
科研通智能强力驱动
Strongly Powered by AbleSci AI