大麻酚
神经保护
大麻素
大麻素受体
化学
神经科学
药理学
葛兰素史克-3
癫痫
信号转导
兴奋剂
受体
生物化学
生物
大麻
心理学
精神科
作者
Han Li,Yuzhi Liu,Danni Tian,Lei Tian,Xingke Ju,Qi Liang,Yongbo Wang,Chengyuan Liang
标识
DOI:10.1016/j.ejmech.2020.112163
摘要
Herein, 11 general types of natural cannabinoids from Cannabis sativa as well as 50 (-)-CBD analogues with therapeutic potential were described. The underlying molecular mechanisms of CBD as a therapeutic candidate for epilepsy and neurodegenerative diseases were comprehensively clarified. CBD indirectly acts as an endogenous cannabinoid receptor agonist to exert its neuroprotective effects. CBD also promotes neuroprotection through different signal transduction pathways mediated indirectly by cannabinoid receptors. Furthermore, CBD prevents the glycogen synthase kinase 3β (GSK-3β) hyperphosphorylation caused by Aβ and may be developed as a new therapeutic candidate for Alzheimer's disease.
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