Refeeding hypophosphataemia in patients on parenteral nutrition: Prevalence, risk factors and predicting its occurrence

Rationale: Patients on parenteral nutrition (PN) may develop refeeding hypophosphataemia (RH) and manifest clinical complications. To assess RH, several diagnostic criteria are used which may account to the highly variable prevalence in the literature (15–62%)1. To identify at-risk patients, the National Institute for Health and Clinical Excellence (NICE) guidelines is used widely but lacks validation. We aim to: 1) determine if the prevalence of RH is influenced by different diagnostic criteria; 2) validate the prognostic accuracy of the NICE guidelines in predicting RH; and 3) identify important risk factors for a new model to better predict RH.