医学
甲状旁腺切除术
骨矿物
原发性甲状旁腺功能亢进
优势比
股骨颈
甲状旁腺功能亢进
单变量分析
泌尿科
甲状旁腺激素
内科学
外科
骨质疏松症
多元分析
钙
作者
Sihua Lü,Maoqi Gong,Yejun Zha,Aimin Cui,Chen Chen,Weitong Sun,Kehan Hua,Wei Tian,Xieyuan Jiang
标识
DOI:10.1186/s12902-020-00622-4
摘要
Abstract Background Studies have shown that the response of bone mineral density (BMD) to parathyroidectomy for symptomatic primary hyperparathyroidism (PHPT) is heterogeneous and difficult to predict. However, the independent factors affecting BMD in PHPT patients after parathyroidectomy remains limited and inconclusive. This study aimed to explore the independent factors affecting BMD changes in symptomatic PHPT patients after parathyroidectomy. Methods This study retrospectively analyzed 105 patients with symptomatic PHPT treated at Beijing Jishuitan Hospital between January 2010 and December 2015. The primary outcome was a > 10% increase in BMD at 3 years after parathyroidectomy compared with the preoperative value, whereas the secondary outcomes were BMD changes at various measurement sites. Results A total of 105 patients with a mean age of 46.37 years were included in this study. Univariate logistic regression analysis indicated that hypertension (odds ratio [OR[: 0.032; 95% confidence interval [CI]: 0.001–0.475; P = 0.012), and parathyroid hormone level (OR: 1.006; 95% CI: 1.004–1.009; P = 0.044) were associated with the > 10% BMD increase. However, these results were not significant after adjustments for potential confounders. Moreover, the BMD values at the lumbar spine, femoral neck, femoral trochanter, Ward’s triangle, and whole body after parathyroidectomy were significantly greater than those before the operation ( P < 0.05). Conclusions This study suggests that patient characteristics were not associated with the > 10% BMD increase. However, the BMD values of the femur and lumbar spine were significantly increased in symptomatic PHPT patients after parathyroidectomy.
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