已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Covid-19: contribution of clinical characteristics and laboratory features for early detection of patients with high risk of severe evolution

医学 降钙素原 急性呼吸窘迫综合征 重症监护室 内科学 白细胞 回顾性队列研究 乳酸脱氢酶 胃肠病学 肌酐 败血症 凝血病 生物化学 化学
作者
Edith Sépulchre,Guillaume Pittie,Violeta Stojkovic,Gentiane Haesbroek,Yves Crama,Michaël Schyns,Henry Paridaens,Jérôme de Marchin,S Degesves,Christian Biemar,Sandrine Boccar,Jean-Marc Senterre,Jean‐Marc Minon
出处
期刊:Acta Clinica Belgica [Taylor & Francis]
卷期号:77 (2): 261-267 被引量:12
标识
DOI:10.1080/17843286.2020.1822078
摘要

The aim of this study was to identify early clinical and laboratory predictive factors of a severe coronavirus disease 2019 (COVID-19).A retrospective study was conducted on adult patients hospitalized for COVID-19 in our hospital. Diagnosis was based on a positive real-time reverse transcription-polymerase chain reaction (RT-PCR) on nasopharyngeal samples. The cohort was divided into two groups, i.e. a favorable evolution (FE) group and an unfavorable evolution (UFE) group, including intensive care unit (ICU) and deceased patients.Results: A total of 198 patients were enrolled in the study, with 138 FE (70%) and 60 UFE (30%). Older age, male gender, comorbidities and dyspnea at admission constituted significantly worse prognosis factors. Among laboratory features, lymphocyte and platelet counts as well as corrected glomerular filtration rate were significantly lower in UFE patients, while neutrophil to lymphocyte ratio, inflammation biomarkers, creatinine, aspartate aminotransferase, lactate dehydrogenase (LDH), glycemia and D-dimer were significantly higher. Procalcitonin and LDH appeared as the most accurate variables according to receiver operating characteristic curves.This Belgian study revealed clinical and laboratory features able to predict high risk of ICU requirement, or even death, at admission time. These results provide a potential tool for patient's triage in a context of pandemic.Abbreviations: COVID-19: coronavirus disease 2019; ARDS: acute respiratory distress syndrome; DIC: disseminated intravascular coagulopathy; MOF: multi-organ failure; RT-PCR: real-time reverse transcription-polymerase chain reaction; UFE: unfavorable evolution; ICU: intensive care unit; EDTA: ethylenediamine tetraacetic acid; WBC: white blood cell count; Hb: hemoglobin level; PCT: procalcitonin; Na: sodium; K: potassium; PT: total protein, CRP: c-reactive protein; Cr: creatinine; ALAT: alanine aminotransferase; ALAT: aspartate aminotransferase; TB: total bilirubin, LDH: lactate dehydrogenase, FERR: ferritin; hs-Tnt: high sensitive-troponin T; cGFR: corrected glomerular filtration rate; QR: quick ratio; DDIM: D-dimer; FIB: fibrinogen; SD: standard deviation; IQR: interquartile ranges; ROC: receiver operating characteristics; ECMO: extracorporeal membrane oxygenation; NLR: neutrophil to lymphocyte ratio; AUC: area under the curve; BMI: body mass index.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
3秒前
3秒前
Jemma发布了新的文献求助10
8秒前
8秒前
初见发布了新的文献求助10
9秒前
aiai发布了新的文献求助10
9秒前
焦立超发布了新的文献求助10
11秒前
马户的崛起完成签到,获得积分10
12秒前
Hodlumm发布了新的文献求助10
13秒前
小瓜完成签到 ,获得积分10
15秒前
封迎松完成签到 ,获得积分10
17秒前
17秒前
wanci应助kingking采纳,获得10
18秒前
一只呆呆完成签到 ,获得积分10
18秒前
ding应助AC赵先生采纳,获得10
18秒前
21秒前
我是老大应助追寻的城采纳,获得10
22秒前
温婉的香氛发布了新的文献求助100
22秒前
JamesPei应助HelloKun采纳,获得10
24秒前
研友_VZG7GZ应助Hodlumm采纳,获得10
25秒前
General发布了新的文献求助10
26秒前
喝杯水再走完成签到,获得积分10
26秒前
27秒前
27秒前
28秒前
28秒前
向日葵完成签到,获得积分10
29秒前
阿叶同学完成签到,获得积分10
29秒前
超人爱吃菠菜完成签到,获得积分10
30秒前
陈志宏发布了新的文献求助10
31秒前
AC赵先生发布了新的文献求助10
32秒前
海盐发布了新的文献求助20
32秒前
32秒前
烟花应助高挑的小虾米采纳,获得10
33秒前
爆米花应助General采纳,获得10
33秒前
33秒前
孙鑫完成签到,获得积分10
34秒前
xia发布了新的文献求助10
35秒前
35秒前
初见完成签到,获得积分10
36秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976455
求助须知:如何正确求助?哪些是违规求助? 3520548
关于积分的说明 11203728
捐赠科研通 3257156
什么是DOI,文献DOI怎么找? 1798618
邀请新用户注册赠送积分活动 877819
科研通“疑难数据库(出版商)”最低求助积分说明 806523