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Blood lipid levels in patients with osteopenia and osteoporosis:a systematic review and meta-analysis

医学 骨量减少 荟萃分析 科克伦图书馆 骨质疏松症 内科学 置信区间 出版偏见 血脂谱 胃肠病学 内分泌学 胆固醇 骨矿物
作者
Hang Zhao,Yong Li,Miaomiao Zhang,Licui Qi,Yong Tang
出处
期刊:Journal of Bone and Mineral Metabolism [Springer Science+Business Media]
卷期号:39 (3): 510-520 被引量:30
标识
DOI:10.1007/s00774-020-01189-9
摘要

Considering the controversial relationship between blood lipid levels and osteopenia and osteoporosis (OP), we performed this meta-analysis. Using specific keywords and related words, we searched PubMed, Embase, and Cochrane Library databases. The Newcastle–Ottawa Scale form was used to evaluate the quality of the literature. According to the inclusion and exclusion criteria, we systematically screened the literature to extract relevant information and data. ReVman 5.3 and Stata 13.0 software were used for statistical analysis. Results were expressed as the mean difference (MD) and 95% confidence interval (95% CI). The heterogeneity test was conducted according to I2 and Q tests. Egger's test was used to quantitatively evaluate publication bias. This analysis involved 12 studies (12,395 subjects). The quality of the literature was acceptable. Among subjects who were not taking lipid-lowering drugs, total cholesterol (TC) (MD = 0.11 mmol/L, 95%CI: − 0.03, 0.25; I2 = 21%; P = 0.36), triglycerides (TG) (MD = − 0.01 mmol/L, 95%CI: − 0.09, 0.07; I2 = 6%; P = 0.34), and low-density lipoprotein cholesterol (LDL-C) (MD = 0.10 mmol/L, 95%CI: 0.00, 0.19; I2 = 0%; P = 0.74) in the osteopenia were not significantly increased/decreased. There were no significant differences in LDL-C (MD = 0.02 mmol/L, 95%CI: − 0.09, 0.13; I2 = 0%; P = 0.74) in postmenopausal women in osteopenia. TG (MD = − 0.04 mmol/L, 95%CI: − 0.14,0.07; I2 = 49%; P = 0.07) was unchanged in the osteoporosis (OP) group in subjects without taking lipid-lowering drugs. HDL-C was elevated in OP group (MD = 0.05 mmol/L, 95%CI: 0.03, 0.07; I2 = 31%; P = 0.15) but not in osteopenia group (MD = 0.01 mmol/L, 95%CI: − 0.01, 0.02; I2 = 38%; P = 0.14) in all subjects. HDL-C was elevated in patients with OP.
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