Advancement of endostatin on inhibiting neoangiogenesis of diabetic retinopathy

Diabetic retinopathy (DR) is a common disease of ophthalmology, often causes irreversible decline of patients' vision, which has two features including macular oedema, diabetic retinal neovascularization.Diabetic retinal neovascularization is one of the most important reasons leading to blindness.Endostatin (ES) is one of the most effective agents inhibiting angiogenesis, whose biological function has a close relationship with its chemical construction.However, its mechanisms of treating diabetic retinal neovascularization are very complicated and remain unclear.Therefore, in this review we summarized several possible mechanisms, including regulating the expression of extracellular matrix, inhibiting the expression of pro-angiogenic factors, and regulating the signaling pathways, by which ES may inhibiting diabetic retinal neovascularization. Key words: Endostatin; Diabetic retinopathy; Ocular neovascularization; Vascular endothelial growth factor