内核层
外层核层
视网膜
神经节细胞层
视网膜
外丛状层
内丛状层
眼科
脉络膜缺失
医学
解剖
神经纤维层
中央凹
光学相干断层摄影术
视神经
视盘
视网膜中央静脉
脉络膜
眼压
眼底(子宫)
光学相干层析成像
青光眼
荧光血管造影
视网膜电图
视网膜色素上皮
生物
中央凹
神经科学
作者
Alessandro Arrigo,Francesco Romanò,Maurizio Battaglia Parodi,Peter Charbel Issa,Johannes Birtel,Francesco Bandello,Robert E. MacLaren
标识
DOI:10.1136/bjophthalmol-2020-316528
摘要
Background To assess retinal layer thickness in choroideremia (CHM) and to reveal its correlation with optical coherence tomography (OCT) angiography (OCTA) findings. Methods The study was designed as an observational, cross-sectional clinical series of patients with CHM, which included 14 CHM eyes and 14 age-matched controls. Multimodal imaging included OCT and OCTA. The vessel density (VD) of superficial capillary (SCP), deep capillary (DCP) and choriocapillaris (CC) plexuses was analysed by OCTA. The apparently preserved retinal islet and atrophic regions were investigated separately. Main outcome measures were as follows: best-corrected visual acuity (BCVA), total retinal layers, ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), ellipsoid zone–retinal pigment epithelium (EZ-RPE) layer, choroidal thickness and VDs of SCP, DCP and of CC. Results Mean BCVA was 0.0±0.0 LogMAR in both groups. GCL, ONL, EZ-RPE and choroid were significantly thinned in CHM, particularly in the atrophic region. OPL was unaffected in the apparently preserved islet, whereas INL and IPL were similarly thinned in the atrophic and apparently preserved retina. DCP appeared severely affected in both regions, while CC was only altered in the atrophic retina. Significant correlations were found between OCT and OCTA parameters. Conclusions Our study showed severe alterations in both outer and inner retinal layers of patients with CHM. The extended retinal involvement might be the consequence of neuronal and vascular trophic factor reduction produced by the primarily altered RPE and/or secondary Müller glial cell reaction.
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