Relationship among pyroptosis, inflammasome and tumor

Pyroptosis is a new way of programmed cell death, a number of researches have found that it is associated with a variety of diseases. Inflammasome and caspase protein family play key roles in regulating pyroptosis.Intracellular pattern recognition receptor oligomers under external stimulus, then assemble with apoptotic speck-like protein containing a caspase recruitment domain and caspase precursor into inflammatory complex body, thus activation of caspase can induce pyroptosis. While as the upstream regulation mechanism of pyroptosis, inflammasome might be double edged sword for tumor growth.On the one hand, inflammasome can inhibit the proliferation of tumor cells by inducing pyroptosis; on the other hand, the cumulative effect of the inflammsome can also form a suitable microenvironment for tumor cells and promote tumor growth. Key words: Neoplasms; Pyroptosis