Ginsenoside Rg1 protects mice against streptozotocin-induced type 1 diabetic by modulating the NLRP3 and Keap1/Nrf2/HO-1 pathways

炎症体 链脲佐菌素 氧化应激 药理学 糖尿病 人参 上睑下垂 半胱氨酸蛋白酶1 活性氧 医学 炎症 内科学 内分泌学 化学 生物化学 替代医学 病理
作者
Yan Gao,Juntong Li,Shifeng Chu,Zhao Zhang,Nai‐Hong Chen,Lin Li,Lan Zhang
出处
期刊:European Journal of Pharmacology [Elsevier BV]
卷期号:866: 172801-172801 被引量:64
标识
DOI:10.1016/j.ejphar.2019.172801
摘要

Ginseng has been traditionally used to treat diabetes mellitus (DM) in China. Ginsenoside Rg1 is a major active ingredient in processed ginseng, which elicits proven biological and pharmacological effects. Although a correlation between nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) and predisposition to type 1 diabetes mellitus (T1DM) has been identified, the mechanism underlying the potential function and activation of NLRP3 inflammasome in DM have not been elucidated to date. The present study aimed to elucidate the effects and underlying mechanism of Rg1 on streptozotocin (STZ)-induced T1DM in mice through short or long-term observation. Concurrently, we intended to explore the relationships between inflammasome, pyroptosis and oxidative stress and the role of NLRP3 and Keap1/Nrf2/HO-1 pathways in the development and progression of DM. Using ELISA and Western blot analysis, we found that Rg1 attenuated abnormally elevated blood glucose, reduced inflammatory factors IL-1β and IL-18 in the blood, decreased ALT and AST levels, promoted insulin secretion, and weakened the function of NLRP3 in mouse liver and pancreas. In addition, Rg1 protected against STZ-induced reactive oxygen species-mediated inflammation by upregulating Nrf2/ARE pathway, which further activated antioxidant enzymes. Interestingly, Rg1 also regulated H3K9 methylation in liver and pancreas, as detected by immunohistochemistry. In summary, these data provide new understanding about the mechanism of Rg1 action, suggesting that it is a potential drug applied for preventing the occurrence and development of T1DM.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
深情安青应助1028181661采纳,获得10
刚刚
求求科研完成签到,获得积分10
刚刚
堵门洞完成签到,获得积分10
1秒前
2秒前
追光者完成签到,获得积分10
2秒前
玻尿酸完成签到,获得积分10
2秒前
2秒前
2秒前
Lemuel完成签到,获得积分10
3秒前
3秒前
zzzz完成签到,获得积分10
4秒前
shower_009完成签到,获得积分10
4秒前
Xinxxx完成签到,获得积分10
4秒前
zyh945发布了新的文献求助10
5秒前
杰尼龟发布了新的文献求助10
5秒前
月月完成签到,获得积分10
5秒前
ohno耶耶耶完成签到,获得积分10
5秒前
wy.he应助gao采纳,获得10
6秒前
JiangSir完成签到,获得积分10
6秒前
过时的茗茗完成签到 ,获得积分10
6秒前
一只小鲨鱼完成签到,获得积分10
6秒前
小月Anna完成签到,获得积分10
6秒前
huoyunli发布了新的文献求助10
7秒前
Pidan完成签到,获得积分10
7秒前
李露露完成签到 ,获得积分10
8秒前
CodeCraft应助sylnd126采纳,获得10
8秒前
碳烤小肥肠完成签到,获得积分10
9秒前
夌隺完成签到,获得积分10
9秒前
木卫三完成签到,获得积分10
10秒前
哈基米完成签到 ,获得积分20
10秒前
鱼饼完成签到 ,获得积分10
10秒前
合适怡完成签到,获得积分10
10秒前
夜已深完成签到,获得积分10
10秒前
安静的从安完成签到,获得积分10
11秒前
健忘的芷荷完成签到,获得积分10
11秒前
11秒前
Banbor2021完成签到,获得积分0
12秒前
hzhang完成签到,获得积分10
12秒前
12秒前
yummy完成签到,获得积分10
13秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968719
求助须知:如何正确求助?哪些是违规求助? 3513608
关于积分的说明 11168681
捐赠科研通 3248960
什么是DOI,文献DOI怎么找? 1794573
邀请新用户注册赠送积分活动 875194
科研通“疑难数据库(出版商)”最低求助积分说明 804716