生物
下调和上调
竞争性内源性RNA
癌症研究
长非编码RNA
肿瘤进展
癌症
肺癌
小RNA
细胞生长
细胞
基因
肿瘤科
遗传学
医学
作者
Fanrui Zeng,Qiongyao Wang,Shuyu Wang,Shumei Liang,Weimei Huang,Ying Guo,Juan Peng,Man Li,Weiliang Zhu,Linlang Guo
出处
期刊:Oncogene
[Springer Nature]
日期:2019-09-02
卷期号:39 (2): 293-307
被引量:94
标识
DOI:10.1038/s41388-019-0984-2
摘要
The functional effects of long noncoding RNAs (lncRNAs) in cancer have been widely recognized. However, there is little research on SCLC-related lncRNAs. Here, long intergenic nonprotein coding RNA 173 (Linc00173) was first shown to be involved in chemoresistance and progression of small-cell lung cancer (SCLC). We found that Linc00173 was highly expressed in SCLC chemoresistant cell lines, and promoted SCLC cells chemoresistance, proliferation, and migration-invasion. Animal studies validated that Linc00173 induced tumor chemoresistance and growth of SCLC in vivo. Moreover, Linc00173 upregulated Etk through functioning as a competitive endogenous RNA (ceRNA) by "sponging" miRNA-218 and led to the upregulation of GSKIP and NDRG1, resulting in the translocation of β-catenin. Importantly, expression analysis revealed that both Linc00173 and Etk were upregulated in SCLC patient samples and exhibiting positive Linc00173/Etk correlation. High expression of Linc00173 closely correlated with chemoresistance, extensive stage, and shorter survival in SCLC patients. Collectively, our study illustrated a Linc00173-mediated process that facilitated chemoresistance and progression in SCLC, which might provide treatment strategy against SCLC.
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