医学
异维甲酸
阿维A
中止
非那雄胺
皮肤病科
维甲酸
回顾性队列研究
联合疗法
内科学
外科
痤疮
胃肠病学
银屑病
维甲酸
前列腺
化学
癌症
基因
生物化学
作者
Adriana Rakowska,Agnieszka Gradzińska,Małgorzata Olszewska,Lidia Rudnicka
出处
期刊:PubMed
日期:2017-10-01
卷期号:16 (10): 988-992
被引量:37
摘要
This study aimed to assess the efficacy of systemic retinoids in treating frontal fibrosing alopecia (FFA). It was based on a retrospective analysis of 54 female patients with FFA treated with: oral isotretinoin at the daily dose of 20 mg (29/54) or acitretin at the daily dose of 20 mg (11/54) or with oral finasteride 5 mg/daily (14/54). The study was conducted between 2007 and 2017. The basic of the study is the measurement of distance between the frontal hairline and the glabellar crease prior to the commencement of treatment and after 6, 12, and 24 months. The treatment with systemic retinoids lasted between 12 and 16 months (the mean duration of treatment was 13.5 months). The primary treatment goal was defined as no further progression of disease after 12 months of treatment, while the secondary treatment goal was defined as no further progression of disease following the discontinuation of systemic retinoids. The primary treatment goal was achieved by 76% (23/29) of patients treated with isotretinoin, 73% (8/11) of patients treated with acitretin, and 43% (6/14) of patients treated with finasteride. The secondary treatment goal was achieved by 72% (21/29) of patients treated with isotretinoin, 73% (8/11) of patients treated with acitretin, and 43% (6/14) of patients treated with finasteride. Thus, the administration of systemic retinoids may be beneficial for the stabilization of frontal hairline in patients with FFA. J Drugs Dermatol. 2017;16(10):988-992. .
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