彭布罗利珠单抗
微卫星不稳定性
医学
封锁
肿瘤科
结直肠癌
内科学
癌症
化疗
DNA错配修复
癌症研究
免疫疗法
微卫星
受体
遗传学
等位基因
生物
基因
作者
Thierry André,Kai‐Keen Shiu,Tae Won Kim,Benny Vittrup Jensen,Lars Henrik Jensen,Cornelis J.A. Punt,Denis Smith,Rocio García‐Carbonero,Manuel Benavides,Peter Gibbs,Christelle De La Fouchardière,Fernando Rivera,Elena Élez,Johanna C. Bendell,Dung T. Le,Takayuki Yoshino,Eric Van Cutsem,Ping Yang,Mohammed Z.H. Farooqui,Patricia Marinello,Luis A. Díaz
标识
DOI：10.1056/nejmoa2017699
摘要
Programmed death 1 (PD-1) blockade has clinical benefit in microsatellite-instability–high (MSI-H) or mismatch-repair–deficient (dMMR) tumors after previous therapy. The efficacy of PD-1 blockade as compared with chemotherapy as first-line therapy for MSI-H–dMMR advanced or metastatic colorectal cancer is unknown.
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