免疫疗法
纳米材料
免疫系统
癌症免疫疗法
纳米技术
癌症
计算生物学
化学
免疫学
生物
材料科学
遗传学
作者
Zhongmin Tang,Yufen Xiao,Na Kong,Chuang LIU,Wei Chen,Xiangang Huang,Daiyun Xu,Jiang Ouyang,Chan Feng,Cong Wang,Junqing Wang,Han Zhang,Wei Tao
标识
DOI:10.1016/j.apsb.2021.05.004
摘要
The field of two-dimensional (2D) nanomaterial-based cancer immunotherapy combines research from multiple subdisciplines of material science, nano-chemistry, in particular nano-biological interactions, immunology, and medicinal chemistry. Most importantly, the “biological identity” of nanomaterials governed by bio-molecular corona in terms of bimolecular types, relative abundance, and conformation at the nanomaterial surface is now believed to influence blood circulation time, bio-distribution, immune response, cellular uptake, and intracellular trafficking. A better understanding of nano-bio interactions can improve utilization of 2D nano-architectures for cancer immunotherapy and immunotheranostics, allowing them to be adapted or modified to treat other immune dysregulation syndromes including autoimmune diseases or inflammation, infection, tissue regeneration, and transplantation. The manuscript reviews the biological interactions and immunotherapeutic applications of 2D nanomaterials, including understanding their interactions with biological molecules of the immune system, summarizes and prospects the applications of 2D nanomaterials in cancer immunotherapy.
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