The risk of menopausal symptoms in premenopausal breast cancer patients and current pharmacological prevention strategies

医学 化疗 乳腺癌 卵巢早衰 肿瘤科 保持生育能力 不育 卵巢早衰 妇科 癌症 内科学 闭经 卵巢癌 怀孕 生育率 人口 环境卫生 生物 遗传学
作者
Yuanyuan Lei,Yeon Hee Park
出处
期刊:Expert Opinion on Drug Safety [Taylor & Francis]
卷期号:20 (10): 1163-1175 被引量:2
标识
DOI:10.1080/14740338.2021.1926980
摘要

Introduction: For young premenopausal breast cancer (BC) patients, adjuvant chemotherapy and other anti-cancer treatments can increase the risk of menopausal symptoms and may cause chemotherapy-related amenorrhea (CRA), infertility and premature ovarian insufficiency (POI).Areas covered: In this report, menopausal symptoms related to anti-cancer treatment are described. Menstrual disturbances associated with the use of adjuvant chemotherapy, endocrine therapy, and targeted therapy against human epidermal growth factor receptor 2 (HER2) in premenopausal women withBC are discussed. To prevent menopausal symptoms, CRA and POI, data on the efficacy of temporary ovarian suppression with gonadotropin-releasing hormone analogues (GnRHa) during chemotherapy are highlighted. Pooled analyses have confirmed that concurrent administration of GnRHa during chemotherapy could significantly reduce the risk of developing chemotherapy-induced POI in premenopausal women with early-stageBC. In addition, reports have suggested that embryo/oocyte cryopreservation may increase the chance of pregnancy after the diagnosis ofBC, although such data remain limited.Expert opinion: Commonly experienced by pre-menopausal women withBC, anti-cancer treatment could cause severe menopausal symptoms. Temporary ovarian suppression with GnRHa during chemotherapy provided asafe and efficient strategy to reduce the likelihood of chemotherapy-induced POI in premenopausal patients with early-stageBC undergoing (neo)-adjuvant chemotherapy.
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