卤化
化学
瞬态(计算机编程)
组合化学
群(周期表)
有机化学
计算机科学
操作系统
作者
Guanghua Kuang,Dandan Liu,Xuerong Chen,Guangyuan Liu,Yang Fu,Yiyuan Peng,Hua Li,Yirong Zhou
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-10-19
卷期号:23 (21): 8402-8406
被引量:20
标识
DOI:10.1021/acs.orglett.1c03131
摘要
A unified method for direct C4-H halogenation of indoles has been accomplished with the assistance of anthranilic acids as suitable transient directing groups. Exclusive site selectivity (one out of five potential reactive sites) as well as good functional group tolerance was obtained to install three kinds of halogen atoms (Cl, Br and I, respectively) by using inexpensive N-halosuccinimides (NXS) as halogen sources under mild conditions. Taking advantage of the rich functional groups in the product, a diversity of nitrogen-containing heterocycles were facily constructed via one-step late-stage derivations.
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