Microstructural Abnormalities of the Dentatorubrothalamic Tract in Cervical Dystonia

肌张力障碍 局灶性肌张力障碍
作者
Rachel Sondergaard,Conrad Rockel,Filomeno Cortese,Yamile Jasaui,Tamara Pringsheim,Justyna R. Sarna,Oury Monchi,Abbas F. Sadikot,Bruce Pike,Davide Martino
出处
期刊:Movement Disorders [Wiley]
卷期号:36 (9): 2192-2198 被引量:11
标识
DOI:10.1002/mds.28649
摘要

The dentatorubrothalamic tract (DRTT) remains understudied in idiopathic cervical dystonia (CD), despite evidence that the pathway is relevant in the pathophysiology of the disorder.The aim of this study was to examine the DRTT in patients with CD using diffusion tensor imaging (DTI)-based tractography.Magnetic resonance imaging scans from 67 participants were collected to calculate diffusion tractography metrics using a binary tractography-based DRTT template. Fractional anisotropy and diffusivity measures of left and right DRTT were computed and compared between 32 subjects with CD and 35 age-matched healthy volunteers.Fractional anisotropy of right DRTT and mean and axial diffusivity of left DRTT were significantly reduced in patients with CD. Similar abnormalities were observed in patients with focal CD and patients with CD without tremor. DTI metrics did not correlate with disease duration or severity.Significant reductions in DTI measures suggest microstructural abnormalities within the DRTT in CD, characterized by a tractography pattern consistent with decreased axonal integrity. © 2021 International Parkinson and Movement Disorder Society.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
郝飞飞完成签到,获得积分10
1秒前
qqz完成签到,获得积分10
2秒前
花花应助淡淡蛋挞采纳,获得10
3秒前
华仔应助虚幻靖易采纳,获得10
3秒前
4秒前
yingying发布了新的文献求助10
5秒前
可爱的函函应助香蕉静芙采纳,获得10
6秒前
张浩发布了新的文献求助10
6秒前
7秒前
fei发布了新的文献求助150
7秒前
8秒前
8秒前
9秒前
依灵完成签到,获得积分10
9秒前
9秒前
充电宝应助mariawang采纳,获得10
10秒前
王哈哈关注了科研通微信公众号
11秒前
kkdkg发布了新的文献求助10
11秒前
时笙发布了新的文献求助10
11秒前
苏利文完成签到,获得积分10
12秒前
12秒前
小二郎应助尔尔采纳,获得30
12秒前
13秒前
小丑鱼儿发布了新的文献求助10
13秒前
14秒前
Rubby应助Sissi采纳,获得10
14秒前
15秒前
隐形夕阳发布了新的文献求助50
16秒前
搞学术的发布了新的文献求助10
16秒前
Freddie发布了新的文献求助10
18秒前
淡淡梦容发布了新的文献求助10
18秒前
18秒前
mmol发布了新的文献求助10
19秒前
可靠的冰烟完成签到,获得积分10
19秒前
Ava应助kkdkg采纳,获得10
20秒前
Bio应助AA简单男孩采纳,获得26
21秒前
搜集达人应助虚幻靖易采纳,获得10
21秒前
Notdodead应助yyds采纳,获得10
21秒前
科研通AI2S应助Lu采纳,获得10
21秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988732
求助须知:如何正确求助?哪些是违规求助? 3531027
关于积分的说明 11252281
捐赠科研通 3269732
什么是DOI,文献DOI怎么找? 1804764
邀请新用户注册赠送积分活动 881869
科研通“疑难数据库(出版商)”最低求助积分说明 809021