A Comparative Discussion of Similarity Based Techniques and Feature Based Techniques for Interaction Prediction of Drugs and Targets

Drug target interaction is the communication between the drug compounds and the proteins present in the human body. The laboratory experiments to verify the drug protein interactions consume a lot of time and are expensive. This creates the requirement of introducing computational approaches for identifying the drug target interactions. The computational approaches that have been introduced for predicting the interactions have broadly been classified into similarity based techniques and feature based techniques. This paper defines the various similarity based as well as the feature based techniques for drug target interaction identification. It highlights the state of the art methods in each category. It also presents a discussion on the comparison of the various categories of similarity and feature based techniques. It also demonstrates their comparison with each other, their merits and demerits.