反向疫苗学
抗生素耐药性
生物技术
抗菌剂
多重耐药
抗生素
生物
医学
微生物学
免疫学
抗原
表位
作者
Asuka Joy Tobuse,Ang Chee Wei,Keng Yoon Yeong
出处
期刊:Life Sciences
[Elsevier]
日期:2022-05-25
卷期号:302: 120660-120660
被引量:8
标识
DOI:10.1016/j.lfs.2022.120660
摘要
With the continuous evolution of bacteria, the global antimicrobial resistance health threat is causing millions of deaths yearly. While depending on antibiotics as a primary treatment has its merits, there are no effective alternatives thus far in the pharmaceutical market against some drug-resistant bacteria. In recent years, vaccinology has become a key topic in scientific research. Combining with the growth of technology, vaccine research is seeing a new light where the process is made faster and more efficient. Although less discussed, bacterial vaccine is a feasible strategy to combat antimicrobial resistance. Some vaccines have shown promising results with good efficacy against numerous multidrug-resistant strains of bacteria. In this review, we aim to discuss the findings from studies utilizing reverse vaccinology for vaccine development against some multidrug-resistant bacteria, as well as provide a summary of multi-year bacterial vaccine studies in clinical trials. The advantages of reverse vaccinology in the generation of new bacterial vaccines are also highlighted. Meanwhile, the limitations and future prospects of bacterial vaccine concludes this review.
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