Normal tissue complication probabilities of lung SABR patients from a UK centre and its implication on personalised radiotherapy

SABR波动模型 医学 并发症 放射治疗 核医学 队列 放射科 外科 内科学 波动性(金融) 随机波动 金融经济学 经济
作者
J. Marsden
出处
期刊:Journal of Radiotherapy in Practice [Cambridge University Press]
卷期号:22
标识
DOI:10.1017/s1460396922000024
摘要

Abstract Introduction: This work reports on the normal tissue complication probabilities (NTCP) from a UK cohort of previously treated peripheral lung SABR patients ( n = 198) supplementing our previous publication on tumour control probabilities (TCP). Each patient was recalculated for alternative schedules. Materials and Methods: NTCP for 3 (54 Gy), 5 (55 and 60 Gy) and 8 (50 Gy) fraction (#) schemes were calculated with the Lyman Kutcher Burman (LKB) model in the software platform ‘Biosuite’ (Version 12·01) for lung and chest wall. Patients treated with 5 # or 8 # were then recomputed for alternative fractionations and doses (3 # and 5 #, for both 55 Gy and 60 Gy). Results: The mean lung NTCP (NTCP LUNG , for the outcome of radiation pneumonitis) was 2·8% (range 0·6 – 10·6). The mean chest wall NTCP (NTCP CW , for the outcome of rib fracture) was 1·4% (range 0·0–55·9). There were no statistically significant differences observed between male and female, tumour status or fractionation groups except for the NTCP LUNG between 5 # and 3 #. When recalculating NTCP and TCP individually, for 8 # patients, no differences were observed between mean TCP, NTCP LUNG or NTCP CW compared with 3 # or 5 # indicating that fractionation reduction is possible. Parity was observed between the 60 Gy group when recalculated for 55 Gy. For the 60 Gy in 5 # group, the NTCP CW increased significantly when recalculated for 3 #. Conclusion: NTCPs achievable with current UK planning techniques have been presented indicating SABR Consortium compliant centres are likely to have low complication population risks (< 3 %). 5 # schedules could be justified for 8 # patients, thereby reducing the number of treatment visits. Where there is a large overlap of PTV and chest wall, this indicates an NTCP/TCP calculation is required to investigate if fractionation reduction is individually appropriate.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
共享精神应助weilu采纳,获得10
1秒前
2秒前
3秒前
卡皮巴拉下班完成签到,获得积分10
3秒前
4秒前
4秒前
大模型应助盛弟采纳,获得10
5秒前
5秒前
6秒前
现代代双发布了新的文献求助10
6秒前
6秒前
传奇3应助叮咚采纳,获得10
7秒前
桐桐应助Deadman采纳,获得10
7秒前
谢俏艳发布了新的文献求助10
8秒前
一只鱼发布了新的文献求助10
8秒前
XoXo完成签到,获得积分10
8秒前
dff发布了新的文献求助10
9秒前
刹那的颜色完成签到,获得积分10
11秒前
GEeZiii发布了新的文献求助10
12秒前
12秒前
31313发布了新的文献求助10
12秒前
科研助手6应助培爷采纳,获得10
13秒前
丽莉完成签到,获得积分10
14秒前
田様应助刘猛闯采纳,获得10
14秒前
14秒前
南星完成签到 ,获得积分10
15秒前
dff完成签到,获得积分10
15秒前
15秒前
zeng完成签到,获得积分10
16秒前
盛弟发布了新的文献求助10
17秒前
18秒前
20秒前
20秒前
20秒前
俞康伟发布了新的文献求助10
20秒前
嗯哼发布了新的文献求助10
21秒前
Rondab应助mariawang采纳,获得10
21秒前
在水一方应助难过的谷芹采纳,获得10
21秒前
量子星尘发布了新的文献求助10
22秒前
22秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988732
求助须知:如何正确求助?哪些是违规求助? 3531027
关于积分的说明 11252281
捐赠科研通 3269732
什么是DOI,文献DOI怎么找? 1804764
邀请新用户注册赠送积分活动 881869
科研通“疑难数据库(出版商)”最低求助积分说明 809021