Normal tissue complication probabilities of lung SABR patients from a UK centre and its implication on personalised radiotherapy

SABR波动模型 医学 并发症 放射治疗 核医学 队列 放射科 外科 内科学 波动性(金融) 随机波动 金融经济学 经济
作者
J. Marsden
出处
期刊:Journal of Radiotherapy in Practice [Cambridge University Press]
卷期号:22
标识
DOI:10.1017/s1460396922000024
摘要

Abstract Introduction: This work reports on the normal tissue complication probabilities (NTCP) from a UK cohort of previously treated peripheral lung SABR patients ( n = 198) supplementing our previous publication on tumour control probabilities (TCP). Each patient was recalculated for alternative schedules. Materials and Methods: NTCP for 3 (54 Gy), 5 (55 and 60 Gy) and 8 (50 Gy) fraction (#) schemes were calculated with the Lyman Kutcher Burman (LKB) model in the software platform ‘Biosuite’ (Version 12·01) for lung and chest wall. Patients treated with 5 # or 8 # were then recomputed for alternative fractionations and doses (3 # and 5 #, for both 55 Gy and 60 Gy). Results: The mean lung NTCP (NTCP LUNG , for the outcome of radiation pneumonitis) was 2·8% (range 0·6 – 10·6). The mean chest wall NTCP (NTCP CW , for the outcome of rib fracture) was 1·4% (range 0·0–55·9). There were no statistically significant differences observed between male and female, tumour status or fractionation groups except for the NTCP LUNG between 5 # and 3 #. When recalculating NTCP and TCP individually, for 8 # patients, no differences were observed between mean TCP, NTCP LUNG or NTCP CW compared with 3 # or 5 # indicating that fractionation reduction is possible. Parity was observed between the 60 Gy group when recalculated for 55 Gy. For the 60 Gy in 5 # group, the NTCP CW increased significantly when recalculated for 3 #. Conclusion: NTCPs achievable with current UK planning techniques have been presented indicating SABR Consortium compliant centres are likely to have low complication population risks (< 3 %). 5 # schedules could be justified for 8 # patients, thereby reducing the number of treatment visits. Where there is a large overlap of PTV and chest wall, this indicates an NTCP/TCP calculation is required to investigate if fractionation reduction is individually appropriate.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
WW完成签到,获得积分10
刚刚
zlttt完成签到,获得积分20
1秒前
852应助momo采纳,获得10
2秒前
此间少年发布了新的文献求助10
2秒前
王汉韬发布了新的文献求助10
2秒前
哈哈完成签到 ,获得积分10
3秒前
英俊的铭应助xn201120采纳,获得10
3秒前
闾丘惜萱完成签到,获得积分10
3秒前
baonali发布了新的文献求助10
5秒前
yyyhhh完成签到,获得积分10
7秒前
ZH完成签到 ,获得积分10
11秒前
11秒前
11秒前
ll完成签到,获得积分10
12秒前
纾缓完成签到,获得积分10
14秒前
潘善若发布了新的文献求助10
14秒前
19秒前
Willy完成签到,获得积分10
20秒前
21秒前
大模型应助史念薇采纳,获得10
21秒前
21秒前
科研通AI2S应助xn201120采纳,获得10
21秒前
23秒前
潘善若发布了新的文献求助10
23秒前
万能图书馆应助GooJohn采纳,获得10
24秒前
梨花酒完成签到,获得积分10
24秒前
阿里山完成签到,获得积分10
25秒前
momo发布了新的文献求助10
26秒前
Amai完成签到,获得积分10
28秒前
Panjiao完成签到 ,获得积分10
32秒前
32秒前
33秒前
34秒前
Owen应助xiaohu采纳,获得10
34秒前
潘善若发布了新的文献求助10
37秒前
Fengliguantou发布了新的文献求助10
38秒前
量子星尘发布了新的文献求助10
39秒前
李健的小迷弟应助momo采纳,获得10
40秒前
42秒前
大模型应助xueyu采纳,获得10
45秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989263
求助须知:如何正确求助?哪些是违规求助? 3531418
关于积分的说明 11253814
捐赠科研通 3270066
什么是DOI,文献DOI怎么找? 1804884
邀请新用户注册赠送积分活动 882084
科研通“疑难数据库(出版商)”最低求助积分说明 809136