光热治疗
双金属片
抗菌活性
纳米颗粒
抗菌剂
光热效应
材料科学
纳米技术
细菌
微生物学
冶金
生物
金属
遗传学
作者
Qiuxian Song,Yihan Liu,Pan Zhang,Wenli Feng,Shaoze Shi,Ninglin Zhou,Xiaohong Chu,Jian Shen
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2022-06-14
卷期号:5 (6): 8621-8630
被引量:19
标识
DOI:10.1021/acsanm.2c02152
摘要
The spread of drug-resistant bacterial infections can lead to serious infectious diseases and pose a significant threat to public health security. Metallic-nano-antibacterial materials are gradually becoming a hot spot for antimicrobial biomaterials research with the advantages of long service life and fast effective bactericidal speed. Considering the construction of a safe and efficient photothermal therapy (PTT) antibacterial platform as a promising strategy for the treatment of bacterial infections, a near-infrared (NIR) bimetallic antibacterial nanoparticle, adenosine 5′-triphosphate (ATP)@Au-Cu nanoparticle (NP), with excellent photothermal conversion efficiency (59.3%) was prepared in this paper; ATP@Au-CuNPs with their multiarm shaped structure and NIR photothermal effect could significantly inhibit the growth of bacteria at the low concentrations. In addition, the cytotoxicity and hemolysis rate of the ATP-coated nanoparticles were reduced considerably, and they also exhibited antibacterial and wound healing-promoting effects in mice wound infection models. On this basis, this paper focuses on the preparation and properties of ATP@Au-CuNPs and explores their biological application in antibacterial therapy.
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