上瘾
伏隔核
自我管理
谷氨酸的
心理学
神经科学
药理学
精神科
医学
多巴胺
内科学
谷氨酸受体
受体
标识
DOI:10.1016/j.biopsych.2022.02.130
摘要
Long Access self-administration procedures (LgA, 6hrs+/day) have become the gold-standard in the addiction field because they produce addiction-like behaviors, and changes in brain not seen following shorter drug access (1-2 hrs/day). However, Zimmer and colleagues recently developed an intermittent access self-administration procedure (IntA) to better model the patterns of cocaine use seen in addicts. IntA produces more robust addiction-like behaviors compared to LgA (cocaine-motivation, reinstatement, and cocaine-seeking) despite much less drug intake. Whether these distinct patterns of cocaine exposure produce similar or different alterations in nucleus accumbens (NAc) function is poorly understood, and there is limited understanding of the behavioral effects of IntA across sex.
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