间充质干细胞
细胞生物学
表型
骨质疏松症
趋化因子
内皮
骨髓
炎症
生物
免疫学
化学
内分泌学
生物化学
基因
作者
Yongzhi Cui,Zhongying Li,Yuanyuan Guo,Xiangbei Qi,Yuehua Yang,Jia Xiong,Rui Li,Jingyu Shi,Weihang Gao,Zhengwei Ren,Guohui Liu,Qingsong Ye,Zhiping Zhang,Dehao Fu
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-07-08
卷期号:16 (7): 11076-11091
被引量:33
标识
DOI:10.1021/acsnano.2c03781
摘要
Recently, bone marrow endothelial cells (BMECs) were found to play an important role in regulating bone homeostasis. However, few studies utilized BMECs to treat bone metabolic diseases including osteoporosis. Here, we reported bioinspired nanovesicles (BNVs) prepared from human induced pluripotent stem cells-derived endothelial cells under hypoxia culture through an extrusion approach. Abundant membrane C-X-C motif chemokine receptor 4 conferred these BNVs bone-targeting ability and the endothelial homology facilitated the BMEC tropism. Due to their unique endogenous miRNA cargos, these BNVs re-educated BMECs to secret cytokines favoring osteogenesis and anti-inflammation. Owing to the conversion of secretory phenotype, the osteogenic differentiation of bone mesenchymal stem cells was facilitated, and the M1-macrophage-dominant pro-inflammatory microenvironment was ameliorated in osteoporotic bones. Taken together, this study proposed BMEC-targeting nanovesicles treating osteoporosis via converting the skeletal endothelium-associated secretory phenotype.
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